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Enabling Transformations with Metal Alkyl Reagents
Speaker:
Taeho Ko
§ Since 2005 - Technical Development Manager with Organometallic Specialties sub-BU of AkzoNobel Polymer Chemicals
§ 17 Years with AkzoNobel – most recently as Production Manager and R&D Manager in
§ Started in ’91 as R&D Engineer in
§ Ph.D. in Chemical Engineering from Rensselaer Polytechnic Institute in ’91.
Metal alkyl reagents have long been used in organic synthesis, especially in the chemical production of active pharmaceutical ingredients (API’s). Metal alkyls - based on aluminum, zinc, boron, and magnesium - enable highly efficient transformations of reduction, cyclization, and addition. In many cases, asymmetric conversions are facilitated by use of metal alkyls. Many noteworthy API’s are synthesized today using AkzoNobel metal alkyls. In this showcase, examples of reactions made possible by diethylzinc (DEZ), diisobutylaluminum hydride (DIBAL-H), trimethylaluminum (TMAL), triethylborane (TEB), diethylaluminum chloride (DEAC), bis-cyclopentadienyl titanium dichloride (TDC), and di-n-butyl magnesium (DNBM) will be presented.
AkzoNobel Polymer Chemicals is a leading manufacturer of organometallic reagents - metal alkyls in particular. More than 40 commercial and developmental alkyls are supplied from our manufacturing plants in
Contact details:
Taeho Ko, Ph.D. (Speaker)
Technical Development Manager,
Akzo Nobel Polymer Chemicals LLC
La Porte, TX 77571
T +1 281 817 9222
F +1 281 476 7556
M +1 281 235 0857
Joseph A. Yanez, Ph.D.
Commercial Manager,
Akzo Nobel Polymer Chemicals LLC
T +1 312 544 7335
F +1 312 544 7408
Ton Elders
Technical Development Manager, EMEIA
Akzo Nobel Polymer Chemicals bv
7400 AA
the
T +31 570 679277
F +31 570 679125
M +31 6 2291 8451